{"id":19043,"date":"2025-11-27T21:13:42","date_gmt":"2025-11-28T00:13:42","guid":{"rendered":"https:\/\/nuevodigitaldeescobar.com.ar\/?p=19043"},"modified":"2025-11-27T21:13:54","modified_gmt":"2025-11-28T00:13:54","slug":"vacuna-argentina-contra-el-melanoma-ya-esta-disponible-y-abre-una-nueva-etapa-en-terapias-contra-el-cancer-de-piel","status":"publish","type":"post","link":"https:\/\/nuevodigitaldeescobar.com.ar\/?p=19043","title":{"rendered":"Vacuna argentina contra el melanoma: ya est\u00e1 disponible y abre una nueva etapa en terapias contra el c\u00e1ncer de piel"},"content":{"rendered":"\n

Argentina sum\u00f3 un avance hist\u00f3rico en la lucha contra el c\u00e1ncer de piel m\u00e1s agresivo. Ya est\u00e1 disponible Vaccimel, la primera vacuna terap\u00e9utica desarrollada en el pa\u00eds para pacientes con melanoma cut\u00e1neo en estadios tempranos. Es un hito cient\u00edfico que coloca al sistema biom\u00e9dico local en la primera l\u00ednea de la inmunoterapia oncol\u00f3gica.<\/em><\/strong><\/p>\n\n\n\n\n\n\n\n

El tratamiento \u2014que solo se aplica con indicaci\u00f3n m\u00e9dica oncol\u00f3gica y en centros especializados\u2014 marca el cierre de m\u00e1s de 30 a\u00f1os de investigaci\u00f3n<\/strong> liderada por el prestigioso cient\u00edfico Jos\u00e9 Mordoh<\/strong>, referente del Conicet y figura central del Instituto Leloir.<\/p>\n\n\n\n

Un desarrollo argentino con impacto global<\/h2>\n\n\n\n

Vaccimel naci\u00f3 a fines de los a\u00f1os 80, cuando Mordoh decidi\u00f3 centrar su trabajo en el melanoma, un tumor cut\u00e1neo de crecimiento r\u00e1pido y elevada mortalidad en casos avanzados.
El proyecto avanz\u00f3 con el apoyo de instituciones como la Fundaci\u00f3n Instituto Leloir<\/strong>, el Instituto Alexander Fleming<\/strong>, el Hospital Mar\u00eda Curie<\/strong> y la Fundaci\u00f3n Sales<\/strong>, siguiendo la l\u00ednea conceptual de figuras como C\u00e9sar Milstein y Ralph Steinman, pioneros en inmunoterapia.<\/p>\n\n\n\n

Tras d\u00e9cadas de investigaci\u00f3n precl\u00ednica y ensayos en pacientes, la ANMAT aprob\u00f3 la vacuna en 2021<\/strong>, permitiendo que el Laboratorio Pablo Cassar\u00e1<\/strong> tomara la posta para producirla y distribuirla. Hoy ya se aplica oficialmente en el Hospital de Oncolog\u00eda Mar\u00eda Curie<\/strong> y se est\u00e1n capacitando centros del interior para ampliar la cobertura.<\/p>\n\n\n\n

C\u00f3mo funciona Vaccimel<\/h2>\n\n\n\n

A diferencia de las vacunas preventivas tradicionales, Vaccimel es terap\u00e9utica<\/strong>: est\u00e1 dirigida a personas que ya fueron diagnosticadas con melanoma y que tienen riesgo de reca\u00edda luego de la cirug\u00eda.<\/p>\n\n\n\n

El tratamiento:<\/p>\n\n\n\n

    \n
  • No previene el c\u00e1ncer<\/strong>, sino que entrena al sistema inmunol\u00f3gico para detectar y destruir c\u00e9lulas tumorales residuales.<\/li>\n\n\n\n
  • Utiliza una estrategia poli-antig\u00e9nica<\/strong>, que presenta m\u00faltiples se\u00f1ales tumorales al sistema inmune para evitar que el melanoma genere resistencia.<\/li>\n\n\n\n
  • Activa a los linfocitos T CD8<\/strong>, c\u00e9lulas clave en la eliminaci\u00f3n de tumores.<\/li>\n\n\n\n
  • Se aplica en 13 dosis durante dos a\u00f1os<\/strong>, con un esquema ambulatorio y poco demandante para el paciente.<\/li>\n<\/ul>\n\n\n\n

    Los ensayos cl\u00ednicos muestran resultados alentadores:
    casi el 70% de los pacientes tratados logra evitar reca\u00eddas<\/strong>, con efectos adversos mucho menores que las terapias tradicionales como el interfer\u00f3n.<\/p>\n\n\n\n

    Terapias celulares: el nuevo cap\u00edtulo de la medicina argentina<\/h2>\n\n\n\n

    Desde el Laboratorio Cassar\u00e1 destacan que Vaccimel forma parte de un proceso m\u00e1s amplio: el desarrollo de terapias celulares avanzadas.
    Argentina lleva m\u00e1s de dos d\u00e9cadas trabajando en este campo y exporta insumos biotecnol\u00f3gicos a m\u00e1s de 100 centros especializados de Estados Unidos.<\/p>\n\n\n\n

    El siguiente paso del laboratorio ser\u00e1 profundizar en terapias CAR-T<\/strong>, que consisten en:<\/p>\n\n\n\n

      \n
    1. Extraer linfocitos del paciente.<\/li>\n\n\n\n
    2. Expandirlos y modificarlos gen\u00e9ticamente para mejorar su capacidad de detectar y destruir tumores.<\/li>\n\n\n\n
    3. Reintroducirlos en el organismo como \u201cc\u00e9lulas de ataque\u201d dirigidas.<\/li>\n<\/ol>\n\n\n\n

      Se trata de tecnolog\u00edas de frontera que ya tienen aprobaci\u00f3n en EE.UU. para leucemias y, m\u00e1s recientemente, para algunos tumores s\u00f3lidos.<\/p>\n\n\n\n

      Melanoma: se\u00f1ales de alerta y prevenci\u00f3n<\/h2>\n\n\n\n

      Aunque suele asociarse al sol, el melanoma puede aparecer en zonas no expuestas: palmas, plantas, u\u00f1as o cuero cabelludo.
      Sus caracter\u00edsticas pueden variar mucho, lo que dificulta la detecci\u00f3n.<\/p>\n\n\n\n

      Para reconocer lesiones sospechosas, los dermat\u00f3logos recomiendan la regla ABCDE<\/strong>:<\/p>\n\n\n\n

        \n
      • A<\/strong>simetr\u00eda<\/li>\n\n\n\n
      • B<\/strong>ordes irregulares<\/li>\n\n\n\n
      • C<\/strong>olor variado<\/li>\n\n\n\n
      • D<\/strong>i\u00e1metro mayor a 6 mm<\/li>\n\n\n\n
      • E<\/strong>voluci\u00f3n: cambios en tama\u00f1o, forma, color o s\u00edntomas<\/li>\n<\/ul>\n\n\n\n

        La detecci\u00f3n temprana es determinante<\/strong>: cuando se extirpa antes de que haga met\u00e1stasis, las probabilidades de curaci\u00f3n son muy altas.<\/p>\n\n\n\n

        Los factores de riesgo m\u00e1s importantes son la exposici\u00f3n solar intensa, piel clara, antecedentes familiares, numerosos lunares, edad avanzada e inmunosupresi\u00f3n.<\/p>\n","protected":false},"excerpt":{"rendered":"

        Argentina sum\u00f3 un avance hist\u00f3rico en la lucha contra el c\u00e1ncer de piel m\u00e1s agresivo. Ya est\u00e1 disponible Vaccimel, la primera vacuna terap\u00e9utica desarrollada en […]<\/p>\n","protected":false},"author":1,"featured_media":19044,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-19043","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nutricion"],"better_featured_image":{"id":19044,"alt_text":"","caption":"","description":"","media_type":"image","media_details":{"width":825,"height":464,"file":"2025\/11\/vaccimel29.png","filesize":1021116,"sizes":{"medium":{"file":"vaccimel29-300x169.png","width":300,"height":169,"mime-type":"image\/png","filesize":47431,"source_url":"https:\/\/nuevodigitaldeescobar.com.ar\/wp-content\/uploads\/2025\/11\/vaccimel29-300x169.png"},"thumbnail":{"file":"vaccimel29-150x150.png","width":150,"height":150,"mime-type":"image\/png","filesize":22827,"source_url":"https:\/\/nuevodigitaldeescobar.com.ar\/wp-content\/uploads\/2025\/11\/vaccimel29-150x150.png"},"medium_large":{"file":"vaccimel29-768x432.png","width":768,"height":432,"mime-type":"image\/png","filesize":260282,"source_url":"https:\/\/nuevodigitaldeescobar.com.ar\/wp-content\/uploads\/2025\/11\/vaccimel29-768x432.png"}},"image_meta":{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0","keywords":[]}},"post":19043,"source_url":"https:\/\/nuevodigitaldeescobar.com.ar\/wp-content\/uploads\/2025\/11\/vaccimel29.png"},"yoast_head":"\nVacuna argentina contra el melanoma: ya est\u00e1 disponible y abre una nueva etapa en terapias contra el c\u00e1ncer de piel - Nuevo Digital de Escobar<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nuevodigitaldeescobar.com.ar\/?p=19043\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vacuna argentina contra el melanoma: ya est\u00e1 disponible y abre una nueva etapa en terapias contra el c\u00e1ncer de piel - Nuevo Digital de Escobar\" \/>\n<meta property=\"og:description\" content=\"Argentina sum\u00f3 un avance hist\u00f3rico en la lucha contra el c\u00e1ncer de piel m\u00e1s agresivo. 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